Multiple roles for Pur-α in cellular and viral regulation
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چکیده
منابع مشابه
HIV Vpr: Roles in Viral Replication and Cellular Metabolism
The auxiliary/non-structural proteins of HIVcan be categorized into 2 groups, essential (Tat and Rev) and accessory (Vpr, Vpx, Vif, Vpu, and Nef). HIV replicates competently in vitro in T-cell lines without the need for accessory gene functions (Subbramanian and Cohen, 1994). However, in primary lymphocytes and macrophages, accessory gene products such as Vpr and Vpx contribute to the efficient...
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The EBNA 2 (Epstein–Barr nuclear antigen 2) transcription factor is essential for B-cell transformation by thecancer-associated EBV (Epstein–Barr virus) and for the continuous proliferation of infected cells. EBNA 2activates transcription from the viral Cp (C promoter) during infection to generate the 120 kb transcriptthat encodes all nuclear antigens required for immortalizatio...
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Tumor necrosis factor (TNF)-alpha and lymphotoxin (LT) alpha/beta play multiple roles in the development and function of the immune system. This article focuses on three important aspects of the effects of these cytokines on the immune response and on autoimmunity. In several experimental systems (Jurkat T cells, murine T-cell hybridomas), TNF-alpha appears to cause a downregulation of signalin...
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Background:Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. Objectives: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. Methods: From 50 patients hospitalized upon...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2009
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.8.3.7585